Matteo Caleo is a Full Professor of Physiology at Dept. of Biomedical Sciences in Padua and Research Associate at CNR Neuroscience Institute in Pisa. He graduated cum laude in Biological Sciences at the Scuola Normale Superiore in Pisa. He obtained his PhD in Neurobiology working with Lamberto Maffei on the role of neurotrophins in activity-dependent plasticity of the visual cortex. He has spent several years as a Research Scientist and then Director of Research at the CNR Neuroscience Institute in Pisa, where he studies plasticity of neuronal connections in pathological brain conditions.
Since October 2018, he is Professor of Physiology at the Dept of Biomedical Sciences, where he is settting up his lab devoted to plasticity and recovery in stroke.
Research interests and career highligths: During his PhD and Post-doc at the Scuola Normale Superiore in Pisa, he worked mainly on the role of neurotrophic factors in the degeneration and plasticity of the visual system. After becoming Group Leader at the CNR Neuroscience Institute in Pisa, he focused on the role of inter-hemispheric, transcallosal connections in the development and plasticity of the visual cortex. He also started a line of research in collaboration with Cesare Montecucco and Gipi Schiavo, devoted to the central effects of botulinum neurotoxins (BoNTs). In particular, he demonstrated that BoNT/A (widely used in clinical neurology for treatment of dystonia and spasticity) is retrogradely transported to the central nervous system following peripheral administration. More recently, his group has focused on the study of neuronal plasticity in different pathological conditions (stroke, brain tumors, epilepsy).