When: 9 April 2026 at 3:00 pm

Where: Sala Seminari VIMM (Fondazione Ricerca Biomedica Avanzata, Via Orus 2, Padova)

Abstract: The increasing awareness on the complexity of the pathogenetic mechanisms in neurodegenerative disorders including Parkinson’s disease (PD), atypical parkinsonisms (multiple system atrophy MSA, progressive supranuclear palsy PSP) and dementias (including Alzheimer’s disease and frontotemporal dementia FTD) in the early/premotor stages is crucial for effective symptomatic treatment, and especially in light of the recent availability of disease-modifying specific therapies (namely monoclonal antibodies against aggregated α-syn and tau). Moreover, the description of different clinical and functional phenotypes according to imaging and neuropsychological biomarkers, especially in the context of atypical parkinsonisms, provides a more tailored and personalized approach.

The integration of morphological and functional data with an accurate biological characterization has become routinely employed in the clinical practice, to support the differential diagnosis and to detect the disease in the early stages.

Blood-based biomarkers including NfL, GFAP and phosphorylated-tau pTau181 can be easily incorporated into clinical practice, both individually and in combination, and have proven useful to distinguish different clinical entitites across a range of complex neurodegenerative disorders, including rare conditions such as atypical parkinsonisms and FTD.

Moreover, phosphorylated-tau pTau217, that has demonstrated significant potential as a biomarker for early amyloid pathology in patients with initial AD, has proven useful in identifying AD co-pathology in the context of other neurodegenerative disorders, particularly in movement disorders where the cognitive burden might be significant.

The detection of phosphorylated α-synuclein and the evaluation of its burden via histology and seed amplification assays in the skin and the gastrointestinal system, together with the concomitant immunological changes occurring in the tissue provide a definite biological characterization in α-synucleinopathies, supporting the clinical diagnosis and differentiating patients according to the specific condition and to the severity.

The evaluation of non-invasive techniques such as Optical Coherence Tomography, showed specific abnormal patterns in the retinal structures in patients diagnosed with PD and MSA, showing potential as an additional biomarker to confirm the clinical diagnosis.

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Quando: 31 marzo 2026 alle ore 17:30

Dove: Aula Magna della Clinica Neurologica oppure online su piattaforma Zoom (https://unipd.link/dns-mart-clinica)

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When: 26 March 2026 at 3:00 pm

Where: Sala Seminari VIMM (Fondazione Ricerca Biomedica Avanzata, Via Orus 2, Padova)

Abstract: In this talk, I will discuss my research lines over the last 10 years, encompassing Cognitive Neuroscience (with a focus on neurophysiological techniques such as EEG and MEG) and Clinical Neuropsychology (with a focus on improving measurement in clinical practice). The presentation will cover my main studies and some proposals on how to bridge these two domains, highlighting key open challenges, and proposing a research agenda to address them. It will also illustrate how this research agenda can benefit from an Open Science approach and discuss the structural and practical obstacles to openness that must be confronted.

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Quando: 17 marzo 2026 alle ore 17:30

Dove: Aula Magna della Clinica Neurologica oppure online su piattaforma Zoom (https://unipd.link/dns-mart-clinica)

The post Applicazione degli ultrasuoni focalizzati a livello cerebrale appeared first on PNC.

Quando: 10 marzo 2026 alle ore 17:30

Dove: Aula Magna della Clinica Neurologica oppure online su piattaforma Zoom (https://unipd.link/dns-mart-clinica)

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The post Il sonno in neurologia: figlio di un Dio minore? appeared first on PNC.

Relatrice: Prof.ssa Alessandra Del Felice, Università di Padova

Quando: 3 marzo 2026 alle ore 17:30

Dove: Aula Magna della Clinica Neurologica oppure online su piattaforma Zoom (https://unipd.link/dns-mart-clinica)

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Relatore: Prof. Carlo Serra (Universitätsspital Zürich)

Quando: 24 febbraio 2026 alle ore 17:30

Dove: Aula Magna della Clinica Neurologica oppure online su piattaforma Zoom (https://unipd.link/dns-mart-clinica)

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Quando: 17 febbraio 2026 alle ore 17:30

Dove: Aula Magna della Clinica Neurologica oppure online su piattaforma Zoom (https://unipd.link/dns-mart-clinica)

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