Brain rhythms for bottom-up and top-down signaling

by Prof. Pascal Fries, Max Planck Institute for Biological Cybernetics, Tübingen, Germany

When: May 16, 2024, at 3:00 pm

Where: Sala Seminari VIMM (Fondazione per la Ricerca Biomedica Avanzata Onlus, Via Orus 2, Padova)

Abstract: Brain networks typically engage in rhythmic synchronization, and this might serve functions, e.g. the processing of stimuli. I will show that repeated visual stimuli induce decreasing firing rates yet enhanced gamma-band synchronization, likely to maintain postsynaptic impact. This impact is indeed optimal for gamma-rhythmic inputs, as I will show by controlling inputs with optogenetics. Optogenetics can also be used to control top-down inputs. I will show that this Opto-Top-Down induces strong, up to several fold, changes in gamma-band synchronization together with much smaller changes in firing rate and no correlation between the two effects.

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