Interindividual differences in the functional connectome at rest: From personalized approaches to biomarkers of cognitive fitness

by Dr. Arianna Menardi, Department of Neurosciences, University of Padova

When: April 11, 2024, at 3:00 pm

Where: Sala Seminari VIMM (Fondazione per la Ricerca Biomedica Avanzata Onlus, Via Orus 2, Padova)

Abstract: The study of the functional connectome allows us to understand the routes of information flow in the brain. When applied to the single subject level, it enables us to map how differences in the region-to-region communication translate into differences in cognitive functioning. In light of this, we are witnessing a shift in the literature, gradually moving from group-level inferences to the study of interindividual differences. Most importantly, the emergence of concepts such as those of Precision Medicine are further pushing the new frontiers in Research towards that of highly individualized protocols in light of the individual clinical-biological makeup. Within this framework, I will present several studies that we have conducted in which the anatomy and functional connectome of the individual were employed to i) personalize stimulation protocols; ii) understand the degree of heritability of the functional connectivity; iii) relate topological efficiency to cognitive fitness. Furthermore, I will overview the importance of resting state activity, challenging its view as solely reflecting baseline activity in the brain, but rather as a biomarker of both high order functioning and pathology, such as in Alzheimer’s Disease.