Focus on Ca2+ signaling dysregulation in astrocytes in the progression of Alzheimer’s disease
by Dr. Micaela Zonta, CNR Neuroscience Institute
When: October 31, 2024, at 3:00 pm
Where: Aula RI (Complesso Vallisneri, Viale Colombo 3, Padova)
Abstract: Alzheimer’s disease (AD) is a chronic, incurable neurodegenerative disorder, characterized by progressive memory loss. Despite the advances in the research on neurodegenerative diseases, the molecular and cellular mechanisms underlying AD pathogenesis and the early events that anticipate the cognitive decline remain poorly understood.
Our research evaluates the involvement of astrocytes in AD pathogenesis, focusing on astrocyte Ca2+ signaling and its dysregulation during AD progression. Indeed, the widely recognized evidence that brain function requires dynamic interactions between neurons and astrocytes implies that both cell types can contribute to brain dysfunction.