fMRI-based Quantitative Mapping of Human Brain Cerebrovascular and Metabolic Function
by prof. Richard Wise, Universita’ degli Studi “G.d’Annunzio” di Chieti-Pescara
When: Mar 18th, 2021 – 3:00 pm
Where: Zoom meeting
Abstract: In the last 30 years blood oxygenation level dependent (BOLD) fMRI has taught us a great detail about human brain organisation. However, it only tells us where brain activity is changing without telling us by how much or what the baseline level of activity is. We and others are working on fMRI methods to map the absolute rate of cerebral metabolic oxygen consumption as a marker of the physiological state of brain tissue in health and disease. Development of these methods has resulted in a toolkit for assessing oxygen consumption and cerebrovascular function (including vascular reactivity and arterial compliance) that is yielding interesting results in our pilot clinical studies in epilepsy and multiple sclerosis and in the study of the healthy brain.