by Prof. Michela Fagiolini (Harvard Medical School, Boston Children’s Hospital and Specialty Chief Editor of Frontiers of Neuroscience Neurodevelopment)
When: June 29, 2023, at 3:00 pm
Where: Sala Seminari VIMM (Building A, Ground Floor, Via Orus 2, Padova)
Understanding the mechanisms underlying experience-dependent brain development and refinement in neurodevelopmental disorders can guide the design of effective target therapies. Over the past years, we have discovered a clear visual cortical phenotype in mouse models of Rett Syndrome(RTT), a monogenic neurodevelopmental disorder, and demonstrated its rescue by environmental, genetic, and pharmacological manipulation of the major inhibitory circuits, Parvalbumin-positive cortical circuits. These results reveal a specific role for MECP2 in the experience-dependent refinement of cortical circuits by regulating the excitation of pivotal inhibitory neurons.